For the CML specific Bcr-Abl gene, the quantitative PCR results showed that the fold decrease in the expression in case of lec-pac-MNPs and pac-MNPs treated cells were 29 and 17 fold respectively whereas that of native pac was 2.4 fold compared to untreated cells (Figure 10 B i, ii). Here, CCL16 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.