GWAS and new generation sequencing disclosed that the response of RA patients to anti-TNF therapy was associated with ATP-binding cassette, subfamily A (ABCA) 1, solute carrier family 44 (SLC44A) 1 gene and granzime B SNP were associated with joint destruction, and protein tyrosine phosphatase, receptor type, C (PTPRC) locus (rs10919563) and TRAF 6 [63–67]. Here, TNF is linked to rheumatoid arthritis.