Several systemic autoimmune diseases cause a prominent IFN signature (interferon-regulated genes) in the affected target tissue which pDCs produce, such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), psoriatic arthritis (PsA), systemic sclerosis (SSc), and Sjögren's syndrome (SjS). The gene discussed is IFNA1; the disease is systemic sclerosis.