IL10 and placental insufficiency: However, our comparison of cytokine profiles in IUGR with and without placental insufficiency showed elevated production of IL-12 and decreased production in IUGR with placental insufficiency; IL-12 is a Th1-inducing cytokine, while IL-10 is a Th2-type cytokine and it is tempting to suggest the possibility of a Th1-bias in IUGR with placental insufficiency when compared to IUGR without placental insufficiency.