Killeen and coworkers [64] recently studied the role of endotoxin and TLR4 in invasion of extracellular matrix (ECM) and have shown that endotoxin promotes tumor cell ECM adhesion and invasion through activation of the urokinase plasminogen activator system (a serine protease that turns plasminogen into enzymically active plasmin responsible for blood clot degradation). Here, TLR4 is linked to neoplasm.