Results in clinical trials have been modest but seem to be much better if the vaccines are used in early stages of the disease, such as, for example, therapy of non-small-cell lung carcinoma (NSCLC) using MAGE-3 antigen combined with MPLA-based adjuvant AS02B rather than in late stages, when the immune system of patients is already severely compromised (reviewed in [136]). The gene discussed is MAGEA3; the disease is non-small cell lung carcinoma.