However, the cancer cells have developed a number of different strategies to escape immune surveillance such as loss of tumor antigen expression, MHC downregulation, expression of Fas-L that can induce apoptosis in activated T cells, secretion of cytokines such as IL-10 (Interleukin-10) or TGF-β (Tumor grow factor-β), or generation of regulatory T (Treg) cells [18]. This evidence concerns the gene TGFB1 and neoplasm.