For this purpose and to optimize the antitumor immunological arms in terms of specificity and long-lasting memory, vaccination with tumor cells transduced with the AIR-1-encoded CIITA, the MHC class II [MHC-II] gene transactivator [124, 125], has been explored with the idea that CIITA-transfected cells may act as “surrogate APC” for optimal triggering of tumor-specific Th cells and thus facilitate the recognition of TAA presented by tumor cell MHC-II molecules. This evidence concerns the gene CIITA and neoplasm.