TGFB1 and Burkitt lymphoma: Using the Burkitt lymphoma model of GC apoptosis, and comparing cells isolated from tonsil tissue, we have shown previously that autocrine TGF-β signalling via the type 1 TGF-β receptor ALK5 contributes to the default apoptotic state of normal GC B cells when they fail to secure survival cues from their microenvironment (death by neglect) [18].