In some lymphomas associated with EBV infection (Burkitt's lymphoma), insensitivity to TGF-β can result from a loss of type II receptor expression [50, 54] which correlates with expression of the latency III program although loss of signalling is not mandatory for antagonising the antiproliferative effects of TGF-β [55]. The gene discussed is TGFB1; the disease is lymphoma.