Beside the direct effect of angiogenic factors on endothelial cells, autocrine and paracrine VEGF/VEGF-related loops were described in hematological malignancies such as acute and chronic leukaemia, myelodysplastic syndromes (MDS), myeloproliferative neoplasms, lymphomas, and multiple myeloma [11]. This evidence concerns the gene VEGFA and plasma cell myeloma.