Compared with homozygous wild-type individuals, those carrying genotypes with variant alleles for ERCC1 IVS5+33A>C had a significant increase in risk (OR, 1.2; 95% CI, 1.0–1.5; P(trend) = 0.04), and the association of ERCC1 with bladder cancer risk seemed to be stronger for cigarette smokers than for never-smokers [6]. This evidence concerns the gene ERCC1 and urinary bladder carcinoma.