Matullo et al. reported that the ERCC1-19007C variant allele (CC+CT versus TT: odds ratio (OR), 0.62; 95% confidence interval (CI), 0.41–0.95) decreased the risk of bladder cancer, which was consistent across smoking groups, although its SNP did not affect carcinogenesis in nonsmoking groups. Here, ERCC1 is linked to urinary bladder cancer.