SERPINE1 and atherosclerosis: AGE stimulate ROS generation in vascular wall cells and subsequently induce redox-sensitive atherosclerosis-related molecular expression such as MCP-1, matrix metalloproteinase-9 (MMP-9), and plasminogen activator inhibitor-1 (PAI-1), all of which could contribute to the formation and destabilization of coronary atherosclerotic plaques [67, 68].