It has recently been recognized that mutations in the PLA2G6 gene that encodes iPLA2β underlie the neurodegenerative disease infantile neuroaxonal dystrophy (INAD) [98] and that a similar disorder develops in mice with a disrupted iPLA2β gene (Malik et al. [99]). The gene discussed is PLA2G6; the disease is neurodegeneration with brain iron accumulation 2A.