We have also reported observations that are consistent with a role for iPLA2β in β-cell mitochondrial function that include that iPLA2β resides in mitochondria in INS-1 insulinoma cells and that its activity provides protection against the effects of staurosporine to induce loss of mitochondrial membrane potential, release of cytochrome c and Smac/DIABLO into cytosol, peroxidation of mitochondrial membranes, and apoptosis [62]. The gene discussed is CYCS; the disease is pancreatic insulinoma.