ACE and hypertensive disorder: Although its expression was similar in location to that of ACE, ACE2 was significantly decreased in RPTs of AT2RKO mice, but was relatively increased in diabetic kidneys of AT2RKO mice (Figures 8(c) and 8(d)), consistent with previously reported counterregulatory interactions between ACE and ACE2, which may play a role in hypertension in diabetes [13, 14, 26].