For example, after 4 weeks of diabetes, there was no further increase in the SBP in either WT or AT2RKO mice (Figure 2(b)) (WT mice, control (N = 10), 112.5 ± 5.78 mmHg; WT diabetic (N = 12), 111.40 ± 4.51 mmHg; WT diabetic with insulin treatment (N = 9), 114 ± 4.27 mmHg; AT2RKO mice, control (N = 13), 130.04 ± 7.00 mmHg; AT2RKO diabetic (N = 12), 132.20 ± 5.62 mmHg; AT2RKO diabetic with insulin treatment (N = 10), 128.97 ± 1.28 mmHg). Here, INS is linked to diabetes mellitus.