INS and Hyperglycemia: As expected, renal hypertrophy (Figure 1(c)) (defined by the ratio of KW versus BW) was present in diabetic animals of both AT2RKO and WT mice; insulin therapy normalized the hyperglycemia (Figure 1(d)) (WT mice (mM), control (N = 15), 7.87 ± 1.59; diabetic (N = 14), 31.43 ± 3.68; diabetic with insulin treatment (N = 13), 15.13 ± 4.18; AT2RKO mice (mM), control (N = 15), 10.16 ± 0.99; diabetic (N = 15), 28.38 ± 3.6; diabetic with insulin treatment (N = 13), 12.64 ± 3.59).