Plasminogen activator inhibitor-1 repression is a hallmark of several cancer cell lines, and this deregulation has been linked to several factors, including p53, TGF-β, and genetic and epigenetic effects (Hiti et al, 1990; Gao et al, 2005; Nagamine, 2008; Shetty et al, 2008). Here, SERPINE1 is linked to cancer.