SERPINE1 and neoplasm: Profiles of mRNA and miRNA steady-state levels were assayed in tissue samples from normal bladder urothelial biopsies, superficial Ta bladder tumours and invasive T1–T4 tumours (Figure 1A) using Affymetrix Exon ST 1.0 microarrays and Exiqon LNA-based microarrays, respectively, and expression of PAI-1 and the clustered miR-143/-145 (Figure 1B) were investigated in detail.