TNF and neoplasm: The inflammatory component of a neoplasm includes a diverse leukocyte population loaded with an assorted array of cytokines, cytotoxic mediators including reactive oxygen species, proteases, membrane-perforating agents and soluble mediators of cell killing such as TNF-α and IFNs (Kuper et al, 2000; Di Carlo et al, 2001; Dumont et al, 2008).