Expression of p-Akt Ser473 (r = 0.179, P = 0.005), p-Akt Thr308 (r = 0.150, P = 0.019), Akt2 (r = 0.250, p < 0.001) and PI3K (r = 0.223, p < 0.001) correlated significantly positive with STS histological grade. The gene discussed is AKT1; the disease is telomere syndrome.