Today it is known that type 2 diabetes is associated with low-grade chronic inflammation that in part emanates from activation of the innate immune system [22] that gives rise to the acute phase response in which CRP plays a fundamental role [22] and several studies have documented the connection between high CRP levels and type 2 diabetes in the presence or absence of obesity [23,24]. The gene discussed is CRP; the disease is obesity due to melanocortin 4 receptor deficiency.