PITX3 and microcephaly: Taking these results further, we analysed LIM2, PAX6, PITX3 and HSF4 genes in four consanguineous Tunisian families with nine affected patients showing ARCC, MR for two brothers from F2 and ARCC, MR and microcephaly for the seven other patients belonging to the four families, but we did not identify any pathogenic mutation.