Recently, Bidinost and coworkers (2006) reported one large Lebanese family where patients with a heterozygous mutation in PITX3 (650delG) had posterior polar cataracts (PPCs), while patients with the same mutation but with the homozygous state had a more severe ocular effect with severe microphthalmia associated with developmental delay and mental retardation. Here, PITX3 is linked to Global developmental delay.