Multivariate analysis identified erbB2 and NFκB overexpression and the presence of hydronephrosis as significant and independent risk factors for CRT resistance, with respective relative risks of 11.8 (P = 0.014), 15.4 (P = 0.024) and 14.3 (P = 0.038, Table 2). The gene discussed is ERBB2; the disease is hydronephrosis.