Among the clinical and molecular variables listed in Table 1, univariate analysis revealed that erbB2 overexpression was significantly associated with CRT resistance (P = 0.003, Table 2); NFκB overexpression, the presence of hydronephrosis, and tumor size ≥5 cm were also associated with CRT resistance despite not reaching statistical significance (P = 0.055, 0.056, and 0.075, respectively). The gene discussed is NFKB1; the disease is hydronephrosis.