In the 16 patients with active TB who were tested, we observed a significantly higher number of IFN-γ-producing T-cells in response to both Rv2628 (BALC median: 24 spot forming cells (SFC)/106 cells, interquartile range (IQR): 4–148 SFC/106 cells; PBMC median: 0 SFC/106 cells, IQR: 0–8 SFC/106 cells) and RD1 antigens (BALC median: 140 SFC/106 cells, IQR: 4–442 SFC/106 cells; PBMC median: 30 SFC/106 cells, IQR: 10–70 SFC/106 cells) (p = 0.006 and p = 0.007, respectively) in BALC than in PBMC (Figure 1 A, B). This evidence concerns the gene PDE6B and tuberculosis.