The up-regulation of B-cell relevant genes as the consequence of MYC silencing is additionally supported by recent results derived from the BL model cell line P493-6 [52] since B-cell related genes such as CD79a/b, CD19, CD20, CD22, CD72, as well as most HLA molecules were down-regulated after MYC induction [52]. The gene discussed is CD22; the disease is Burkitt lymphoma.