Here we establish another strong linkage between PcG and MYC by showing that 14 PcG complex genes are MYC targets including EZH1/2, EED and BMI1. Given the important role of PcG in B-cell development, lymphomagenesis, and tumor stem cell development [44] it will be interesting to further analyze the relation between MYC, PcG and PcG target genes. This evidence concerns the gene EED and neoplasm.