KLK6 has been associated with increased invasiveness, growth and angiogenesis, by virtue of its ability to degrade ECM components such as denatured type I collagen, fibronectin, vitronectin and laminin [54], or activate PAR-2 signaling [55] which has been implicated in mediating cellular proliferation in colon cancer cells [56]. Here, FN1 is linked to malignant colon neoplasm.