Only eight of the events (all hotspot sites) associated with genomic disorders, including 22q11.2 deletion (TBX1, DiGeorge syndrome), 17p12 duplication (PMP22, Charcot-Marie-Tooth disease), and 15q11.2q13.1 duplication (UBE3A and SNRPN) (Table S9). This evidence concerns the gene TBX1 and 22q11.2 deletion syndrome.