CHRNA7 and Monosomy 22q13: Interestingly, 20/77 CNVs (16 hotspot and four non-hotspot sites) mapped to a known genomic disorder site, including those associated with variable phenotypes such as 15q13.1q13.3 (CHRNA7), 16p11.2 proximal (TBX6; two cases) and distal (SH2B1) hotspots, 16p13.11 (MYH11; three cases), 17q12 (TCF2), and 3q29 (DLG1) as well as syndromic regions such as 7q11.23 (Williams syndrome), 17q21.31 (MAPT), 5q35 (Sotos syndrome), 8p23.1, 22q13 (Phelan-McDermid syndrome) [24] and 1p36 [25].