For example, Pseudomonas aeruginosa, a major pathogen in the lungs of cystic fibrosis patients, and Vibrio cholerae, the causative agent of cholera, have been shown to secrete multiple enzymes with ATP-modifying activities, such as adenylate kinase, ATPase, and 5′-nucleotidase [87]–[89]. Here, DNAH8 is linked to vibrio infectious disease.