These new predictions include RAS, PLCG1, IAP, TNF, NFAT, GRB2, FYN, SMAD, P27, and Cytoskeleton signaling, which are predicted to stabilize at ON in T-LGL leukemia and GAP, SOCS, TRADD, ZAP70, and CREB which are predicted to stabilize at OFF. Here, FYN is linked to T-cell large granular lymphocyte leukemia.