Among patients with diabetes free of CAC at baseline, Hp 2 appeared to have an allele-dose effect on development of CAC: Hp 2-1 OR: 1.72 (1.09-2.71) and Hp 2-2 OR: 2.94 (1.87-4.65), compared to Hp 1-1 and adjusting for age and sex (Figure 1). Here, HP is linked to diabetes mellitus.