As the amniotic fluid bathes the developing lung and is an important source of surfactant [32], it is tempting to speculate that the high sFlt1 concentrations in the amniotic fluid of women with preterm gestational hypertension or preeclampsia may inhibit VEGF signaling, leading to surfactant deficiency. The gene discussed is VEGFA; the disease is hyperinsulinemic hypoglycemia, familial, 4.