Angiogenesis is an important process for growth, progression, and metastasis of solid tumors, and the inhibitor of the vascular endothelial growth factor (VEGF) bevacizumab (Bev) is currently approved for the treatment of colon, lung, breast, and clear cell renal carcinoma in the metastatic setting [5]. Here, VEGFA is linked to clear cell renal carcinoma.