CD4 and myeloid sarcoma: Our results disclose a new unreported aspect that is related to the deviated immunity in MS that includes the increased production of proinflammatory cytokines, such as IFN-γ from T cells and IL-12, IL-18 and IL-23 from monocytes and dendritic cells [23–27], the loss of function of Treg cells, such as CD4+CD25+ T cells and CD46-mediated Tr-1 cells [28, 29], as well as of suppressor CD8+ T cells [30, 31] and the reduction in immune-mediated neurotrophins, and noggin production [20, 32, 33].