Stimulation with anti CD3/CD28 mAb upregulated the expression of ErbB4 to a significantly lesser extent in the MS patients group, the average of the ratios of ErbB4 MFI between with anti-CD3/CD28 mAb and isotype controls (average ratio ± S.D = 3.5 ± 1.6) as compared to HC (6.2 ± 1.6, P = 0.005). This evidence concerns the gene CD28 and myeloid sarcoma.