STAT3 and intrahepatic cholangiocarcinoma: ICC staining of LN-18 cells demonstrated that as similar as the situation in UW228-3 cells (data not shown), STAT3 nuclear translocation was distinctly inhibited by AG490 (Figure 6A), accompanied with remarkably decreased fraction of G1 phase cells (2.6%) and increased apoptotic cell death (8.1%; Figure 6B).