PTK2B and hepatocellular carcinoma: Moreover, overexpression of FAK in HCC patients is significantly correlated with larger tumor size, advanced new Edmonson's stage and shorter disease-free survival while positive overexpression of Pyk2 is significantly correlated with larger tumor size, advanced new Edmonson's stage, venous invasion, shorter overall survival and shorter disease-free survival, suggesting that Pyk2 is an important prognostic marker in addition to FAK [22].