Moreover, phosphorylated Akt was also demonstrated to be overexpressed in MHCC97L-vector generated tumor in subcutaneous nude mice model and orthotopic model by western blot (Fig. 4E).These results indicated that Pyk2 overexpression had a significant effect on tumor growth by activation of pAkt, as well as inhibition of tumor necrosis and apoptosis upon cisplatin treatment. The gene discussed is AKT1; the disease is neoplasm.