For advanced fibrosis and cirrhosis (stages 3–4) the AUROC obtained was 0.863, which compares very favorably with the AUROC obtained for severe disease with combinations of other markers, e.g. AUROC = 0.76 for significant fibrosis and AUROC = 0.82 for cirrhosis in an AST to platelet ratio [22], AUROC = 0.81 for cirrhosis with combined HA, TIMP-1, and platelet count [23] and AUROC = 0.84 with Fibrotest [21]. The gene discussed is TIMP1; the disease is Cirrhosis.