Besides TLR2 that recognizes malarial glycosylphosphatidylinositol [26], TLR9 gained attention since hemozoin or malaria pigment, which is a crystalline detoxification product of heme formed in the food vacuole of parasites during hemoglobin digestion, has been described as a ligand of TLR9 able to induce immune activation [27], [28]. Here, TLR9 is linked to malaria.