PTGS2 and systemic sclerosis: Expression of COX1a, COX1b, and COX2 which regulate prostaglandin synthesis thereby suppressing the synthesis of collagen [49], [50]; and SOCS2, which acts to suppress insulin growth factor 1 (IGF1) and growth hormone (GH) mediated deposition of excessive collagen [51] were significantly downregulated in untreated SSc cells (Figure 7).