CCN5 and systemic sclerosis: Several genes known to be involved in the regulation of production and maintenance of the extracellular matrix (ECM) or in the development of fibrosis, including fibronectin 1 (FN1), insulin growth factor binding protein 7 (IGFBP7), plasminogen activator urokinase (PLAU), Wnt-inducible signaling protein 2 (WISP2), were upregulated in SSc-derived dermal fibroblasts compared to normal dermal fibroblasts.