TGFB1 and neoplasm: Radiographic image analysis in MDA-MB-231 tumor-bearing mice treated with either control antibody (13C4, 10 mg/kg, Figure 2a, left panel, arrow indicating osteolytic damage) or anti-TGFβ antibody (1D11, 10 mg/kg, Figure 2a, right panel) has indicated that the average number of osteolytic lesions was reduced by more than three-fold (Figure 2b; p<0.001) and the average lesion area was reduced ten-fold in the anti-TGFβ treatment group when compared with control (Figure 2c; p<0.001).