TGFB1 and breast cancer: MicroCT analysis of tibia from mice bearing MDA-MB-231 human breast cancer cells in bone following intra-cardiac injection demonstrated that a 4-week treatment with anti-TGFβ antibody 1D11 resulted in an approximately 5-fold increase in the overall bone volume when compared with the isotype control 13C4 treated group (Figure 4b; p<0.001).