EDN1 and Hypertension: ET-1 also contributes to hypertension in deoxycorticosterone acetate (DOCA)-salt hypertensive rats and DOCA-salt treated SHRs [6]–[8], and ET receptor antagonists (LU135252, A127722.5 and bosentan) had been shown to lower blood pressure in various experimental hypertensive models [9]–[12].