This exploratory evaluation of gene-environment interactions for a broad spectrum of NHL risk factors with implicated NHL risk loci, HLA-DRB1*01:01 and AH 8.1, suggests that environmental exposures may interact with HLA-DRB1*01:01 and sun-related exposures with AH 8.1 in altering NHL risk. Here, HLA-DRB1 is linked to non-Hodgkin lymphoma.