Although we previously evaluated the joint effects between TNF G-308A and NHL risk factors [8], we have since demonstrated that the ancestral haplotype 8.1 (AH 8.1: HLA-A*01-B*08-DR*03-TNFG-308A) whereby HLA alleles are in linkage disequilibrium with TNF, is associated with DLBCL [9]. The gene discussed is TNF; the disease is diffuse large B-cell lymphoma.