Previously, we demonstrated that the phosphorothioate-modified “10–23” DNAzymes specifically targeted at the LMP1 mRNA could significantly down-regulate the expression of LMP1 in a nasopharyngeal carcinoma cell (NPC) and affected the down-stream pathways activated by LMP1, including the NF-κB pathway [18], [19]. This evidence concerns the gene NFKB1 and nasopharyngeal carcinoma.