GNB1L and schizophrenia: This observation, combined with the findings of reduced expression of GNB1L in postmortem brains of schizophrenics [Ishiguro et al., 2010] and the effect of heterozygous deletion of Gnbl1 on prepulse inhibition, a schizophrenia endophenotype, in a mouse model [Paylor et al., 2006], suggest that GNB1L is associated with the schizophrenia phenotype observed in del22q11.2.