In melanoma cells, the NF-κB pathway can be altered by upregulation of the p50 and p65 NF-κB subunits (Meyskens et al, 1999; McNulty et al, 2001) and downregulation of the NF-κB inhibitor, IκB (Yang and Richmond, 2001; Dhawan and Richmond, 2002). The gene discussed is NFKB1; the disease is melanoma.