NFKB1 and melanoma: As increased NF-κB activity appears to play an important role in maintaining the aggressive nature of melanoma (Yang and Richmond, 2001), and melanin pigment affects the sensitivity of melanoma cells to chemotherapy (Slominski et al, 2004), we analysed the relationship between pigmentation and NF-κB activity in a well-defined cell culture model of inducible melanin pigmentation (Brozyna et al, 2008; Slominski et al, 2009).