This approach is also justified by recent clinical and epidemiological studies in melanoma, showing vitamin D levels to be associated with lower melanoma incidence (Egan, 2009; Newton-Bishop et al, 2009; Pinczewski and Slominski, 2010), and histopathological analyses showing that progression of melanoma is linked to reduction of VDR expression and lack of VDR expression is accompanied by shorter overall survival time (Brozyna et al, 2011). The gene discussed is VDR; the disease is melanoma.