WIF1 and acute myeloid leukemia: Jost et al (2008) also did not find any prognostic impact of aberrant methylation in SFRP promoters in 100 AML patients. Contrary to our findings, Chim et al (2006) pointed out that Wif-1 methylation was an independent poor prognostic factor for DFS and Valencia et al (2009) showed AML patients with two or more methylated Wnt inhibitor genes had poorer RFS, but not OS, in the subgroup of patients 60 years or younger with intermediate-risk cytogenetics by multivariate analysis.