Acute myeloid leukaemia patients with hypermethylation of any SFRP gene as a whole had higher frequency of CD19 (P=0.0004), CD7 (P=0.0144), and CD34 expression (P=0.012), but had lower frequency of CD14 expression (P=0.0395) on the leukaemia cells. The gene discussed is CD7; the disease is acute myeloid leukemia.