YBX1 and neoplasm: To date, a large number of scientific articles have left little doubt that YB-1, a multifunctional protein, regulates transcription and translation by shuttling between the cytoplasm and the nucleus influencing tumour growth (Schittek et al, 2007), chemotherapy resistance (Bargou et al, 1997; Kuwano et al, 2004), and EMT (Evdokimova et al, 2009).