Taken into account that YB-1 expression is linked to multi drug resistance in various tumour entities so far as well as against EGFR-tailored drugs (Kashihara et al, 2009) YB-1 expression was also found to be also involved in cancer stem cell biology (To et al, 2010) and trastuzumab resistance (Dhillon et al, 2010). This evidence concerns the gene YBX1 and cancer.