It is established that YB-1 expression and localisation could affect many critical aspects of tumour biology as it is involved in fundamental processes such as mRNA splicing (Stickeler et al, 2001), cell cycle (Jurchott et al, 2003), drug resistance (Bargou et al, 1997), DNA repair (Gaudreault et al, 2004) and translational regulation (Evdokimova et al, 2001). Here, YBX1 is linked to neoplasm.