Upon nuclear translocation, which is believed to be mediated by Akt and Erk through phosphorylation (Coles et al, 2005; Sutherland et al, 2005), YB-1 regulates the transcription activity by binding to gene promoter regions containing the Y-box motif, and among others, YB-1 thus may activate gene expression of the EGFR (Stratford et al, 2007), matrix metalloproteinase 2 (Mertens et al, 1997), and MET (Finkbeiner et al, 2009), which are associated with tumour cell adhesion, invasion and metastasis in HNSCC. This evidence concerns the gene MET and head and neck squamous cell carcinoma.