YBX1 and neoplasm: Taken into account that YB-1 expression is linked to multi drug resistance in various tumour entities so far as well as against EGFR-tailored drugs (Kashihara et al, 2009) YB-1 expression was also found to be also involved in cancer stem cell biology (To et al, 2010) and trastuzumab resistance (Dhillon et al, 2010).