For example, in transgenic mouse models of SOD1-associated ALS, SOD1 antibody reactive inclusions have been detected in spinal motor neurons of mice expressing the H46R [14], G85R [4,10], and G93A [7,8,10,13] mutants; and in spinal astrocytes of mice expressing the G85R [4] mutant. This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.