It has been shown that in gallstone patients, ileal ASBT expression is diminished, and that this is associated with low cytosolic ileal lipid binding protein (ILBP) and basolateral organic solute bile acid exporter (OSTα-OSTβ) expression indicating impaired enterohepatic circulation of bile salts at least in a subset of patients with cholelithiasis [25,26]. This evidence concerns the gene FABP6 and cholelithiasis.