ERBB2 and adenocarcinoma: Table 4 summarizes clinicopathological differences observed between primary GCs with or without HER2 amplification. In particular, HER2 amplified GCs were associated with the intestinal type of adenocarcinoma by the Lauren classification (P < 0.001). However, no differences were observed between HER2 amplified and non-amplified cases in terms of age, sex or pathological stage. Kaplan–Meyer survival analysis also showed no difference between HER2 amplified and non-amplified cases (data not shown).