KDR and glioblastoma: Further, very recently a novel therapeutic approach has been proposed, targeting the VEGFR expression via the introduction of an artificial transcriptional regulator (Zinc finger, [98]) eventually mediated by an adenovirus [93], inducing a downregulation of VEGFR by acting on the VEGFR promoter, resulting in marked antitumor effect on a human glioblastoma xenograft model.