These include epidermal growth factor (EGF), platelet-derived growth factor (PDGF), insulin-like growth factor 1 (IGF-1), and their specific receptors (EGFR, PDGFR, and IGFR), all of which are involved in autocrine or paracrine signaling in gliomas [3–7]. The gene discussed is EGFR; the disease is glioma.