It was also showed that a combination of ATRA and IFN-γ expressed higher levels of HLA class II and HLA-DM molecules in glioblastoma T98G and U87MG cells than IFN-c alone [121], suggesting that the combination of ATRA with INF-γ may overcome the defect in class II-mediated immune recognition of glioblastoma [121]. The gene discussed is IFNG; the disease is glioblastoma.