AKT1 and central nervous system cancer: These receptors with tyrosine kinase activity also exist in constitutively active mutant forms in gliomas [7], regulating several signaling pathways such as phosphoinositide-3-kinase/AKT-protein kinase B (PI3K/AKT-PKB), RAS/mitogen-activated protein kinase (MAPK), and phospholipase C/protein kinase C (PLC/PKC).