EGFR and glioblastoma: A very promising and interesting evolution of the EGFR targeting is due to the discovery that many forms of glioblastoma express several splicing variants of the receptor, among which the most represented is that called EGFRvIII lacking a portion of the extracellular domain corresponding to exons 2–7, giving rise to a protein of 145 kDa [67, 68].