Proliferation of the large-cell carcinoma cell line A549, which exhibited moderately activated HER1 and IGF-1R pathways, was inhibited by the PI3K inhibitor BEZ-235 and by the IGF-1R inhibitor BMS-536924 and weakly by the MEK inhibitor PD-325901. The gene discussed is IGF1R; the disease is large cell carcinoma.