Chemoprevention against colorectal [5-9] and prostate [10,11] neoplasia has been demonstrated with aspirin and some NSAIDs, like ibuprofen and sulindac, as well as with difluoromethylornithine (DFMO), an ornithine decarboxylase (ODC) inhibitor that decreases polyamine biosynthesis. Here, ODC1 is linked to neoplasm.