As shown in Figure 1 (see also Table S3 in Additional file 1), the SNPs rs5029924, rs5029937 and rs2230926 in TNFAIP3 were observed to be significantly associated with onset age and most of the clinical subphenotypes, including malar rash, arthritis, serositis, neurologic disorder, hematologic disorder, immunologic disorder and antinuclear antibody (OR = 1.67 to 3.18, P = 0.021 to 0.001). The gene discussed is TNFAIP3; the disease is nervous system disorder.