Significance was observed for rs5029924, rs5029937 and rs2230926 (TNFAIP3) in the paired patient groups of onset age and subphenotypes of serositis and neurologic disorder; for rs6590330 and rs4937333 (ETS1) in the paired patient groups of onset age and subphenotypes of malar rash, photosensitivity, arthritis, serositis and renal disorder; and for rs7708392 (TNIP1) in the paired patient groups of antinuclear antibody (Figure 1). This evidence concerns the gene TNFAIP3 and arthritic joint disease.