Risk alleles of TNFAIP3 and ETS1 were found to be significantly enriched in subphenotypes of malar rash, arthritis, hematologic, neurologic and subphenotype antinuclear antibody - with the highest OR when comparing the patient group with the subphenotype with the controls, and the lowest OR when comparing the patient group without the subphenotype with the controls. This evidence concerns the gene ETS1 and arthritic joint disease.