For ETS1, SNPs rs6590330 and rs4937333 showed significant association with onset age and multiple clinical subphenotypes, including malar rash, photosensitivity, arthritis, serositis, renal disorder, hematologic disorder, immunologic disorder and antinuclear antibody (OR = 1.50 to 1.98, P = 0.003 to 1.9 × 10-7). The gene discussed is ETS1; the disease is Arthritis.