APOE and atherosclerosis: For example, it has been reported that apolipoprotein E-deficient (ApoE-/-) BM chimeric mice with AT1R-/- blood cells and AT1R+/+ vessel wall components exhibit blunted Ang II-enhanced atherosclerosis, comparable to that noted in AT1R-/-/ApoE-/- double knockout mice, suggesting that AT1R on BM derived cells is critical for the progression of atherosclerosis [4].