For example, tumor C3H BF had Wnt1 as a CIS in addition to Tcf7l2, while insertion of MMTV at Antxr1 and Wnt3 in tumor Balb 5 resulted in the expression of both CISs (Fig. 1 and Tables 2 and 3). The gene discussed is ANTXR1; the disease is cold-induced sweating syndrome.