We also examined whether PRDM5 methylation/silencing is correlated with enhanced WNT/β-catenin signaling in tumor cell lines, and found that the active form of β-catenin was accumulated in cell lines with methylated and silenced PRDM5, with significant lower level of active β-catenin detected in PRDM5-expressing cell lines (Figure 8C). Here, PRDM5 is linked to neoplasm.